Vinyl Chloride Exposure Liver

How can exposures be reduced.

Vinyl chloride exposure liver.

Cases of liver angiosarcoma have been reported among individuals employed in pvc fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to pvc dust and the risk of lung cancer mortality. Meta analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality. The causal link between vinyl chloride exposure and lung cancer must be further investigated. The evidence of a causal link between vinyl chloride exposure and liver cancer is anyhow confirmed.

There is inadequate ascertainment of unequivocal diagnoses. Vinyl chloride is also known to cause fibrosis scarring of the liver which is a risk factor for hepatocellular carcinoma. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. Shipped as a liquefied compressed gas.

In the very first study about the dangers of vinyl chloride published by patty in 1930 it was disclosed that exposure of test animals to just a single short term high dose of vinyl chloride caused liver damage. Occupational safety health administration provides information about exposure limits to vinyl chloride. Angiosarcoma and hepatocellular carcinoma. Liver side effects of vinyl chloride.

However the data on which this conclusion is based is incomplete. Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. 1 3 butadiene ethylene oxide and vinyl halides vinyl fluoride vinyl chloride and vinyl bromide.

In 1949 a russian publication discussed the finding that vinyl chloride caused liver injury among workers. The evidence for a carcinogenic risk has been extended to jobs associated with poly vinyl chloride exposure. Bofetta p matisane l mundt ka dell ld. In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though only on the basis of the few cases available.

Chloroethene chloroethylene ethylene monochloride monochloroethene monochloroethylene vc vcm vinyl chloride monomer vcm colorless gas or liquid below 7 f with a pleasant odor at high concentrations. Vinyl chloride exposure is associated with an increased risk of a rare form of liver cancer hepatic angiosarcoma as well as brain and lung cancers lymphoma and leukemia. Iarc monographs on the evaluation of carcinogenic risks to humans vol 97. Liver damage is the most serious health risk of vinyl chloride.